Summary

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The text discusses splice variants of genes, specifically highlighting the cases of DUT:p and LEPR:p. DUT:p utilizes a splice variant that eliminates the targeting peptide while preserving the enzymatic function through exon substitution. Conversely, LEPR:p, a previously promising drug target, ultimately proved problematic and contributed to the decline of protein engineering efforts in the late 80s/early 90s due to issues with its ligand.

Title

THE GPM

Description

THE GPM

Keywords

sequence, protein, splice, human, exons, canon, exon, data, folly, form, proteomics, peptide, tissue, terminal, variant, have, peptides

NS Lookup

A 24.76.97.129

Dates

Created 2026-03-09

Updated 2026-03-09

Summarized 2026-03-09